Biochemistry

 

The focus of the Biochemistry track is to advance your knowledge of the chemistry associated with biological systems. The contents is applicable both in science, medicine, drug discovery, diagnostics and in industrial uses of proteins. The specialization offers courses in which the theoretical content is integrated with training of skills in laboratory work and projects. The courses are closely linked to ongoing research that spans a wide range of biochemical areas such as quantitative enzymology, drug discovery, directed evolution of proteins and nano-biochemistry.

The Biochemistry track offers an opportunity for students with basic knowledge in biochemistry, molecular biology or medical sciences to achieve a deeper understanding of biochemical problems. The curriculum consists of courses in both chemistry and biology.

Programme outline in detail >> 
 

Profile Courses

Molecular Recognition in Biological Systems, 15 credits

You learn mechanisms of molecular recognition involving biomolecules, in particular proteins, based on thermodynamic and stereochemical principles. Which forces influence molecular interactions, and how can these be understood in terms of binding strength and selectivity in complex biological environments. The course also treats the design of molecules for interaction with biomolecules. Laboratory work includes surface plasmon resonance, phage display and peptide synthesis. For more information - see the syllabus.

Enzymology and Bioorganic Catalysis, 15 credits

In this course you study relationships between structure and function of enzyme-catalyzed reactions, both theoretically and through practical exercises. The course content imcludes thermodynamic aspects of catalysis, in particular enzyme catalysis, enzyme kinetics and catalytic mechanisms, stereo chemistry, directed evolution of enzymes and industrial applications. Laboratory work includes: determining kinetic mechanisms by steady-state and pre-steady-state kinetics, kinetic isotope effects and pH dependency. For more information - see the syllabus.

Research


At the Department of Biochemistry and Organic Chemistry active research in the fields of molecular recognition, enzymology, directed evolution of proteins and bio-catalysis is conducted.
The research groups offer opportunities for degree projects related to the absolute cutting edge of modern biochemistry.

 

Here we analyse chemical building blocks that can be used to "construct" new drugs. With the help of our studies it is possible to choose building blocks that bind efficiently to the protein whose function the drug is designed to interfere with. The detailed understanding of how the protein interacts with the substances can be used to optimise the medical effect. The research group has developed strategies for how to use this type of analyses also for this optimisation and has started a company commercialising their knowledge for faster drug development.