Chemical Biology


The Chemical Biology track studies biological problems from a chemical perspective and it offers a broadening of the understanding of biological systems and the specific chemical conditions that prevail. As an organic chemist, you will learn how synthesis methodology can be optimized to suit complex systems or aqueous solutions. Special focus lies on how small organic molecules interact with typical biomolecules such as proteins and nucleic acids.

Chemical Biology addresses both biologists and chemists, but basic knowledge and skills in organic chemistry are required. The curriculum consists of courses in chemistry.

Programme outline in detail >>


Profile Courses

Chemical Molecular Design, 10 credits

Here you will learn to design molecules with desired functionality to address a given scientific problem. Contents include cost evaluation in relation to the likelihood of success and possible benefits from a given molecule. Examples of target molecules are modified proteins and other catalysts. For more information - see the syllabus.

Molecular Recognition in Biological Systems, 15 credits

You learn mechanisms of molecular recognition involving biomolecules, in particular proteins, based on thermodynamic and stereochemical principles. Which forces influence molecular interactions, and how can these be understood in terms of binding strength and selectivity in complex biological environments. The course also treats the design of molecules for interaction with biomolecules. Laboratory work includes surface plasmon resonance, phage display and peptide synthesis. For more information - see the syllabus.

Chemical libraries and efficient synthesis, 15 credits

The course covers basic and advanced methods in organic synthesis, including diversity oriented synthesis for the production of large selections of compounds that cover the chemical space. Development of synthetic routes for the efficient production of molecular libraries with great diversity. Particular emphasis is given to chemical genetics, synthesis methodology for high-throughput and solid-phase synthesis, analysis and monitoring of combinatorial libraries. Since the course is laboratory intense, skills to work independently in an organic-chemical laboratory are expected. For more information - see the course plan.

 

"If you love biology and chemistry, consider focusing your academic career on the intersection between the two."
 

Research


At the Department of Biochemistry and Organic Chemistry, research related to chemical biology is conducetd in a variety of areas. Examples of projects are the organic chemistry of proteins, synthetic ion channels, photosensitive peptidomimetica, drug design and molecular recognition for the development of new diagnostic tools.

 

In a research project that develops nanobiosensors this robot is frequently used. It can among other things (pipettera) and (flourisera) 380 samples at a time. One example of appliance of this research is protein analyses in health care.